表面改性
化学
叠氮
区域选择性
组合化学
光催化
脱质子化
分子
有机化学
催化作用
光催化
离子
物理化学
作者
Kei Murakami,Shuya Yamada,Toshiyuki Kaneda,Kenichiro Itami
出处
期刊:Chemical Reviews
[American Chemical Society]
日期:2017-04-26
卷期号:117 (13): 9302-9332
被引量:405
标识
DOI:10.1021/acs.chemrev.7b00021
摘要
Azines, which are six-membered aromatic compounds containing one or more nitrogen atoms, serve as ubiquitous structural cores of aromatic species with important applications in biological and materials sciences. Among a variety of synthetic approaches toward azines, C–H functionalization represents the most rapid and atom-economical transformation, and it is advantageous for the late-stage functionalization of azine-containing functional molecules. Since azines have several C–H bonds with different reactivities, the development of new reactions that allow for the functionalization of azines in a regioselective fashion has comprised a central issue. This review describes recent advances in the C–H functionalization of azines categorized as follows: (1) SNAr reactions, (2) radical reactions, (3) deprotonation/functionalization, and (4) metal-catalyzed reactions.
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