姜黄素
氧化应激
丙二醛
谷胱甘肽
化学
活性氧
酒精性肝病
药理学
抗氧化剂
乙醇
体内
生物化学
医学
内科学
生物
酶
生物技术
肝硬化
作者
Shuang Rong,Yong Zhao,Wei Bao,Xiao Xiao,Di Wang,Andreas K. Nüssler,Yan Hong,Pin Mei Yao,Liegang Liu
出处
期刊:Phytomedicine
[Elsevier]
日期:2012-04-01
卷期号:19 (6): 545-550
被引量:81
标识
DOI:10.1016/j.phymed.2011.12.006
摘要
Our previous study found that curcumin, a major active component of turmeric, could ameliorate ethanol-induced hepatocytes oxidative stress in vitro. The objective of this work was to investigate the effect of curcumin on chronic alcoholic liver disease (ALD) in vivo. Ethanol-exposed (2.4 g/kg/day ethanol for the initial 4 weeks and 4 g/kg/day for another 2 weeks) Balb/c mice were simultaneously treated with curcumin for 6 weeks. The results showed that curcumin attenuated ethanol-induced histopathological changes of the liver and ameliorated the evident release of cellular alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Ethanol exposure resulted in reactive oxygen species (ROS) generation, malondialdehyde (MDA) elevation, glutathione (GSH) depletion and antioxidant defense system impairment, which were significantly reversed by curcumin treatment. In conclusion, curcumin provided protection against chronic ALD and the mechanism might be related to the alleviation of oxidative damage.
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