炔烃
薗头偶联反应
钯
催化作用
芳基
组合化学
化学
三氟甲基
多米诺骨牌
级联反应
有机化学
烷基
作者
Zixian Chen,Jianbo Zhu,Haibo Xie,Shan Li,Yikang Wu,Yuefa Gong
摘要
A new, rapid and high-yielding method to prepare 3,4-disubstituted 2-trifluoromethylquinolines by a palladium catalyzed tandem Sonogashira–alkyne carbocyclization of β-trifluoromethyl β-enaminoketones with arynes is described. Moderate to excellent yields have been achieved under mild conditions. This reaction can also be expanded to the non-fluorine containing substrates. The reaction mechanism is also discussed.
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