谷胱甘肽
结合
羟基化
代谢物
化学
细胞色素P450
酶
新陈代谢
微粒体
致癌物
生物化学
代谢途径
细胞色素
尿
立体化学
数学分析
数学
作者
Kunna Li,Ying Zou,Yan Wang,Mengyue Zhou,Jing Li,Rong Tan,Shiyu Zhang,Weiwei Li,Jiang Zheng
出处
期刊:Xenobiotica
[Informa]
日期:2022-04-03
卷期号:52 (4): 360-369
被引量:2
标识
DOI:10.1080/00498254.2022.2079022
摘要
2-Methylnaphthalene (2-MN) is an environmental pollutant. Studies have shown that 2-MN is teratogenic, carcinogenic, and cytotoxic. However, the mechanisms of 2-MN induced toxicities remain unclear.This study aimed to characterise reactive metabolites of 2-MN, to define the metabolic pathway, and to determine the enzymes participating in the metabolic activation.A hydroxylation metabolite of 2-MN, 2-naphthalenemethanol (2-NM), was observed in 2-MN-containing mouse liver microsomes.A glutathione (GSH) conjugate was detected in mouse S9 incubations fortified with 2-MN and GSH. A GSH conjugate and an NAC conjugate were found in mouse liver and urine, respectively, in animals given 2-MN. Hepatic protein covalent binding derived from 2-NM was observed in animals administered 2-MN.Cytochrome P450 enzymes and sulfotransferases participated in the metabolic activation of 2-MN.
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