柠檬苦素
代谢组学
化学
代谢组
亲水作用色谱法
液相色谱-质谱法
串联质谱法
色谱法
氨基酸
质谱法
食品科学
高效液相色谱法
生物化学
作者
Xiaoyue Zhang,Zhao-Ju Zhu,Sipei Ren,Yuchan Deng,Jianing Xu,Si-Meng Zhang,Jin‐Ming Gao,Qiang Zhang
出处
期刊:Food Chemistry
[Elsevier]
日期:2022-09-01
卷期号:387: 132933-132933
被引量:8
标识
DOI:10.1016/j.foodchem.2022.132933
摘要
The fruit juice food industry produces huge waste annually, mainly Citrus peel and seeds. We investigated their chemical composition using hydrophilic interaction chromatography (HILIC-) and reverse phase liquid chromatography tandem mass spectrometry (RPLC-MS/MS), revealing 277 compounds, mainly containing flavonoids and limonoids. As the primary representative component in Citrus waste, limonin was selected to be explored new bio-functions. We applied Zebrafish larvae to study the metabolomic response invoked by limonin. The differential metabolites (DMs) varied depending on the exposing concentration of limonin. Enrichment analysis indicated that the identified DMs related to inflammation and neurologic disorders, including epilepsy which were newly discovered for limonoids and Citrus waste. Limonin was found to restore amino acids disorder to take neuroprotection against epilepsy. Our findings provided a new bio-function and purpose for Citrus waste and limonoids. Also, we demonstrated a concise case to repurpose food waste for new applications under metabolome investigation.
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