CRISPR System Discovery, History, and Future Perspective

Chapter 8 CRISPR System Discovery, History, and Future Perspective Faizan Ali, Faizan Ali Department of Plant Pathology, University of Agriculture, Agriculture University Road, Faisalabad, 38000 PakistanSearch for more papers by this authorAkhtar Hameed, Akhtar Hameed Department of Plant Pathology, Institute of Plant Protection, MNS-University of Agriculture Multan, Old Shujabad Road, Multan, 59220 PakistanSearch for more papers by this authorAbdul Rehman, Abdul Rehman Department of Plant Pathology, University of Agriculture, Agriculture University Road, Faisalabad, 38000 PakistanSearch for more papers by this authorSohaib Sarfraz, Sohaib Sarfraz Department of Plant Pathology, University of Agriculture, Agriculture University Road, Faisalabad, 38000 PakistanSearch for more papers by this authorNasir A. Rajput, Nasir A. Rajput Department of Plant Pathology, University of Agriculture, Agriculture University Road, Faisalabad, 38000 PakistanSearch for more papers by this authorMuhammad Atiq, Muhammad Atiq Department of Plant Pathology, University of Agriculture, Agriculture University Road, Faisalabad, 38000 PakistanSearch for more papers by this author Faizan Ali, Faizan Ali Department of Plant Pathology, University of Agriculture, Agriculture University Road, Faisalabad, 38000 PakistanSearch for more papers by this authorAkhtar Hameed, Akhtar Hameed Department of Plant Pathology, Institute of Plant Protection, MNS-University of Agriculture Multan, Old Shujabad Road, Multan, 59220 PakistanSearch for more papers by this authorAbdul Rehman, Abdul Rehman Department of Plant Pathology, University of Agriculture, Agriculture University Road, Faisalabad, 38000 PakistanSearch for more papers by this authorSohaib Sarfraz, Sohaib Sarfraz Department of Plant Pathology, University of Agriculture, Agriculture University Road, Faisalabad, 38000 PakistanSearch for more papers by this authorNasir A. Rajput, Nasir A. Rajput Department of Plant Pathology, University of Agriculture, Agriculture University Road, Faisalabad, 38000 PakistanSearch for more papers by this authorMuhammad Atiq, Muhammad Atiq Department of Plant Pathology, University of Agriculture, Agriculture University Road, Faisalabad, 38000 PakistanSearch for more papers by this author Book Editor(s):Sajid Fiaz, Sajid Fiaz University of Haripur, Haripur, PakistanSearch for more papers by this authorChannapatna S. Prakash, Channapatna S. Prakash Tuskegee University, Alabama, United StatesSearch for more papers by this author First published: 29 March 2024 https://doi.org/10.1002/9781394209156.ch8 AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onEmailFacebookTwitterLinkedInRedditWechat Summary The following chapter looks into the transformative impact of CRISPR-Cas genome editing technology on genetics, agriculture, and beyond. It explores the origins of CRISPR systems from bacterial defense mechanisms to versatile tools, emphasizing their role in bacterial immunity, viral defense, and synthetic biology. CRISPR's pivotal role in precision gene editing, with comparison to other editing technologies, application of CRISPR-based genome editing in plants, showcasing its ability to enhance traits, induce epigenetic modifications, and enable multiplex editing. The ethical considerations and responsible innovation in gene editing are discussed. Future of the CRISPR technology has the potential to redefine genetic manipulation, potentially addressing climate challenges, and propelling synthetic biology advancements. This chapter highlights CRISPR's profound potential to revolutionize molecular biology, agriculture, and biotechnology while urging careful ethical and scientific deliberation. References Araldi , R.P. , Khalil , C. , Grignet , P.H. et al. ( 2020 ). 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