Safety review of antithrombotic therapy options after left atrial appendage occlusion

Introduction Left atrial appendage occlusion (LAAO) is a viable alternative to anticoagulation for treatment in patients with Non-valvular Atrial fibrillation (NVAF) who cannot tolerate anticoagulation. Post-procedure patients are generally prescribed Oral anticoagulation (OAC) for 45 days while the device is undergoing endothelialization, following which patients are continued on antiplatelet agents. Recommendations for antithrombotic agents following LAAO arrived by consensus which are not tolerated by all patients.