生物
结直肠癌
吲哚试验
色氨酸
微生物群
肠道菌群
免疫系统
癌症
新陈代谢
微生物学
免疫学
生物信息学
生物化学
遗传学
氨基酸
作者
Yuanyuan Liu,Zhangming Pei,Tong Pan,Hongchao Wang,Wei Chen,Wenwei Liu
标识
DOI:10.1016/j.micres.2023.127392
摘要
Tryptophan (Trp) functions in host-disease interactions. Its metabolism is a multi-pathway process. Indole and its derivatives are Trp metabolites unique to the human gut microbiota. Changes in Trp metabolism have also been detected in colorectal cancer (CRC). Here, combined with the existing CRC biomarkers, we ascribed it to the altered bacteria having the indole-producing ability by making a genomic prediction. We also reviewed the anti-inflammatory and possible anti-cancer mechanisms of indoles, including their effects on tumor cells, the ability to repair the gut barrier, regulation of the host immune system, and provide resistance against oxidative stress. Indole and its derivatives, along with related bacteria, could be targeted as auxiliary strategies to restrain cancer development in the future.
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