脂肪生成
内科学
内分泌学
非酒精性脂肪肝
脂肪肝
肥胖
胰岛素抵抗
脂质代谢
医学
生物
呼吸交换率
疾病
心率
血压
作者
Robson Damasceno de Lima,Renan Fudoli Lins Vieira,Vitor Rosetto Muñoz,Amandine Chaix,Ana Paula Azevêdo Macêdo,Gabriel Calheiros Antunes,Maíra Felonato,Renata Rosseto Braga,Susana Castelo Branco Ramos Nakandakari,Rafael Calais Gaspar,Adelino Sánchez Ramos da Silva,Dennys Esper Cintra,Leandro Pereira de Moura,Rania A. Mekary,Eduardo Rochete Ropelle,José Rodrigo Pauli
出处
期刊:American Journal of Physiology-endocrinology and Metabolism
[American Physiological Society]
日期:2023-11-01
卷期号:325 (5): E513-E528
标识
DOI:10.1152/ajpendo.00129.2023
摘要
Nonalcoholic fatty liver disease (NAFLD), a condition characterized by the accumulation of fat in the liver, is estimated to be the most common liver disease worldwide. Obesity is a major risk factor and contributor, and, accordingly, weight loss can improve NAFLD. Previous studies in preclinical models of diet-induced obesity and fatty liver disease have shown the independent benefits of resistance exercise training (RT) and time-restricted feeding (TRF) in preventing weight gain and hepatic build-up of fat. Here, we tested the combined effect of TRF and RT on obesity and NAFLD in mice fed a high-fat diet. Our results showed that both TRF-8-h food access in the active phase-and RT-consisting of three weekly sessions of ladder climbing-attenuated body weight gain, improved glycemic homeostasis, and decreased the accumulation of lipids in the liver. TRF combined with RT improved the respiratory exchange rate, energy expenditure, and mitochondrial respiration in the liver. Furthermore, gene expression analysis in the liver revealed lower mRNA expression of lipogenesis and inflammation genes along with increased mRNA of fatty acid oxidation genes in the TRF + RT group. Importantly, combined TRF + RT was shown to be more efficient in preventing obesity and metabolic disorders. In conclusion, TRF and RT exert complementary actions compared with isolated interventions, with significant effects on metabolic disorders and NAFLD in mice.NEW & NOTEWORTHY Whether time-restricted feeding (TRF) combined with resistance exercise training (RT) may be more efficient compared with these interventions alone is still unclear. We show that when combined with RT, TRF provided additional benefits, being more effective in increasing energy expenditure, preventing weight gain, and regulating glycemic homeostasis than each intervention alone. Thus, our results demonstrate that TRF and RT have complementary actions on some synergistic pathways that prevented obesity and hepatic liver accumulation.
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