医学
嵌合抗原受体
细胞疗法
移植
临床试验
经济短缺
门诊护理
重症监护医学
汽车T细胞治疗
肿瘤科
内科学
癌症
免疫疗法
医疗保健
细胞
语言学
哲学
遗传学
政府(语言学)
生物
经济
经济增长
作者
Olalekan O. Oluwole,Bhagirathbhai Dholaria,Tristan Knight,Tania Jain,Frederick L. Locke,Linda Ramsdell,Sarah Nikiforow,Hamza Hashmi,Kathy Mooney,Shakthi Bhaskar,Katrina Morris,Katie S. Gatwood,Brittney Baer,Larry D. Anderson,Mehdi Hamadani
标识
DOI:10.1016/j.jtct.2023.11.008
摘要
The first series of chimeric antigen receptor T (CAR-T) cell therapy products were approved in 2017 – 2019 and have shown remarkable efficacy in both clinical trial and real-world setting, but at the cost of prolonged patient hospitalization. As the toxicity management protocols were refined, the concept of cellular therapy administered in the outpatient setting gained steam, and single institutions began to perform certain aspects of CAR-T monitoring in the outpatient setting for select patients. However, there are many considerations for a successful outpatient program. In anticipation of increasing utilization of CAR-T-cell therapy in the outpatient setting as a mechanism to overcome frequent hospital bed shortages and high cost of inpatient care, the American Society for Transplantation and Cellular Therapy (ASTCT) convened a group of experts in hematology, oncology, and cellular therapy to provide a comprehensive review of the existing publications on outpatient CAR-T-cell therapy, discuss selected ongoing clinical trials of outpatient CAR-T, and describe strategies to optimize safety without compromising efficacy for patients treated and monitored in the outpatient setting.
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