Asymmetric Brønsted base-catalyzed aza-Michael addition and [3 + 2] cycloaddition reactions of N-ester acylhydrazones and enones

We reported the first enantioselective Brønsted base-catalyzed aza-Michael addition and stepwise cascade [3+2] cycloaddition between acylhydrazones and unsaturated ketones. The enantio-enriched aza-Michael adducts can be transformed into 2-pyrazolines.