马尿酸
甲苯
化学
磷酸盐
尿
检出限
生物传感器
发光
核化学
色谱法
有机化学
生物化学
材料科学
光电子学
作者
Mingyuan Lei,Fayuan Ge,Tingting Wu,Xinde Duan,Zhiqiang Shi,He‐Gen Zheng
出处
期刊:Dalton Transactions
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:51 (39): 14924-14929
被引量:4
摘要
Rapid and accurate determination of biomarkers of human poisoning in real urine is of great significance for the assessment of health status. Herein, a luminescent urea-functionalized metal-organic framework (MOF), {[Cd(L)0.5(bpbix)]·x(solv)}n (1) (H4L = 5,5'-(((naphthalene-1,5-diylbis(azanediyl))bis(carbonyl))bis(azanediyl))diisophthalic acid; bpbix = 4,4'-bis((1H-imidazol-1-yl)methyl)biphenyl), has been successfully synthesized, and exhibits good stability in aqueous solutions in the normal urinary pH range and real urine. Complex 1 can serve as a dual-responsive luminescent biosensor for the detection of diphenyl phosphate (DPP) and hippuric acid (HA) as biomarkers of flame retardant triphenyl phosphate and toluene poisoning, and shows the advantages of high sensitivity, rapid response, good anti-interference capability, and reversibility. More significantly, complex 1 is successfully applied to the sensitive and accurate detection of DPP and HA in real urine with satisfactory recoveries. This work presents a dual-responsive luminescent MOF-based biosensor for simple, rapid, accurate, and reversible determination of urinary DPP and HA, which has promising application potential for the diagnosis of diseases related to triphenyl phosphate and toluene poisoning.
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