氧化还原
化学
活性氧
细胞凋亡
生物物理学
细胞内
程序性细胞死亡
热疗
癌症研究
纳米技术
材料科学
生物化学
生物
无机化学
古生物学
作者
Yuan Liang,Pengpeng Lei,Ran An,Pengye Du,Shuyu Liu,Yi Wu,Hongjie Zhang
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-12-27
被引量:1
标识
DOI:10.1021/acs.nanolett.3c04063
摘要
Highly soluble salts and gas mediated therapies are emerging antitumor strategies. However, the therapeutic efficacy remains restricted by difficulty in delivering them to the tumor site and poorly controlled release in deep tissues. Here, an intelligent wireless photoactivated targeted nanosystem is designed for delivering LiCl and H2 to tumors for therapy. LiCl causes cell death by inhibiting the activity of GSK-3β. H2 selectively interacts with reactive oxygen species in the tumor, leading to redox stress, which induces apoptosis. The significant heat generated by the nanosystem not only kills tumor cells but also accelerates the dissolution of LiCl and the release of H2. The rapid dissolution of LiCl leads to a surge in intracellular osmotic pressure, which further intensifies the redox stress response and enhances the efficiency of therapy. The nanosystem shows efficient tumor therapeutic capability via synergistic effects of hyperthermia/redox stress amplification/GSK-3β activity inhibition.
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