医学
碳离子放射治疗
鼻咽癌
接收机工作特性
肿瘤科
切断
内科学
放射治疗
比例危险模型
体积热力学
核医学
泌尿科
胃肠病学
物理
量子力学
作者
Jiyi Hu,Qingting Huang,Weixu Hu,Fei Liang,Jing Gao,Jing Yang,Xianxin Qiu,Haojiong Zhang,Guangyuan Zhang,Jiade J. Lu,Lin Kong
出处
期刊:Oral Oncology
[Elsevier]
日期:2024-04-01
卷期号:151: 106683-106683
标识
DOI:10.1016/j.oraloncology.2024.106683
摘要
Although carbon ion radiation therapy (CIRT) substantially improves the overall survival (OS) of patients with LR-NPC, approximately 40% of the patients may develop local recurrence. The purpose of study is to assess the value of tumor volume (TV) as a predictive tool to guide individualized CIRT.Consecutive patients with LR-NPC treated using CIRT at Shanghai Proton and Heavy Ion Center between April 2015 and May 2019 were included. TV before CIRT was delineated and calculated. The generalized additive Cox model was used to examine the relationship between TV and OS and local progression-free survival (LPFS). A cutoff value of tumor volume was identified to best discriminate patients with different 2-year OS rates, using receiver operating characteristic (ROC) analysis.A total of 157 patients were enrolled. The median tumor volume was 22.49 (2.52-90.13) ml. In the univariable analyses, tumor volume was significantly associated with OS (p < 0.001) and LPFS (p = 0.01). The relationships with OS (p = 0.009) and LPFS (p = 0.020) remained significant in multivariable analyses. Using ROC analysis, a TV of 26.69 ml was identified to predict the 2-year OS rate. To facilitate potential clinical use, 25 ml was designated as the final cutoff value. The 2-year OS and LPFS rates were 88.6 % vs 62.3 %, and 54.7 % vs 35.5 %, for patients with a TV ≤ 25 ml and > 25 ml, respectively.Tumor volume could predict the OS and LPFS of patients. We propose that tumor volume should be considered in the risk stratification and CIRT-based treatment for patients with LR-NPC.
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