溶解循环
基因组
生物
粪便
噬菌体
微生物群
细菌病毒
普雷沃菌属
人类粪便
微生物学
温带气候
微生物生态学
生态学
动物
细菌
病毒
遗传学
大肠杆菌
基因
作者
Andrey N. Shkoporov,Orla O’Regan,Linda K. Smith,Ekaterina V. Khokhlova,Lorraine A. Draper,R. Paul Ross,Colin Hill
出处
期刊:iScience
[Elsevier]
日期:2024-02-01
卷期号:27 (2): 108778-108778
标识
DOI:10.1016/j.isci.2023.108778
摘要
Bacteriophages are a major component of the gut microbiome and are believed to play a role in establishment and stabilization of microbial communities by influencing taxonomic and functional diversity. We show that the activity of lytic and temperate phages can also significantly affect bacterial community structure in a model of extended colonic retention. Intact fresh human feces were incubated anaerobically at 37°C without homogenization and subjected to metagenomic sequencing. We observed subject-specific blooms and collapses of selected bacteriophage and bacterial populations within some individuals. Most notable were striking collapses of Prevotella populations accompanied by increases in specific bacteriophages. In a number of cases, we even observed a shift from one bacterial "enterotype" to another within 48 h. These results confirm that intact feces represents a highly dynamic ecological system and suggests that colonic retention time could have a profound effect on microbiome composition, including a significant impact by bacteriophages.
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