生物
自噬
基因
细胞生物学
有机体
疾病
遗传学
ATG16L1
细胞器
医学
病理
细胞凋亡
作者
Beth Levine,Guido Kroemer
出处
期刊:Cell
[Elsevier]
日期:2019-01-01
卷期号:176 (1-2): 11-42
被引量:1741
标识
DOI:10.1016/j.cell.2018.09.048
摘要
The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy-related (ATG) genes. Definitive etiological links exist between mutations in genes that control autophagy and human disease, especially neurodegenerative, inflammatory disorders and cancer. Autophagy selectively targets dysfunctional organelles, intracellular microbes, and pathogenic proteins, and deficiencies in these processes may lead to disease. Moreover, ATG genes have diverse physiologically important roles in other membrane-trafficking and signaling pathways. This Review discusses the biological functions of autophagy genes from the perspective of understanding-and potentially reversing-the pathophysiology of human disease and aging.
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