对映体药物
二乙基锌
化学
二醇
对映选择合成
催化作用
有机化学
基质(水族馆)
药物化学
海洋学
地质学
作者
Zhaojun Li,Xinmiao Liang,Boshun Wan,Fan Wu
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2004-09-22
卷期号:2004 (17): 2805-2808
被引量:2
标识
DOI:10.1055/s-2004-831238
摘要
The enantiopure 1,1′-spirobiindane-7,7′-diol (SPINOL) and its 4,4′-derivatives 4,4′-diiodo-1,1′-spirobiindane-7,7′-diol (DISPINOL) and 4,4′-dimethyl-1,1′-spirobiindane-7,7′-diol (DMSPINOL) have been synthesized effectively via (1S)-(-)-4,4′-dibromo-1,1′-spirobiindane-7,7′-diyl bismenthyl carbonate with BuLi following the cleavage of the bismenthyl carbonate. Their absolute configurations were assigned by chemical correlation. They are also applied in the form of their Ti-alkoxides as catalysts for the addition of diethylzinc to aldehydes. The addition reactions proceeded with high conversions and enantioselectivities up to 88%. The effect of substitution of the substrate was studied.
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