神经科学
γ-氨基丁酸受体
抑制性突触后电位
跨膜蛋白
兴奋性突触后电位
神经传递
离子通道
受体
功能(生物学)
生物
细胞生物学
生物化学
作者
Wenyan Han,Ryan D. Shepard,Wei Lü
标识
DOI:10.1016/j.tins.2020.10.011
摘要
The vast majority of fast inhibitory transmission in the brain is mediated by GABA acting on GABAA receptors (GABAARs), which provides inhibitory balance to excitatory drive and controls neuronal output. GABAARs are also effectively targeted by clinically important drugs for treatment in a number of neurological disorders. It has long been hypothesized that function and pharmacology of GABAARs are determined by the channel pore-forming subunits. However, recent studies have provided new dimensions in studying GABAARs due to several transmembrane proteins that interact with GABAARs and modulate their trafficking and function. In this review, we summarize recent findings on these novel GABAAR transmembrane regulators and highlight a potential avenue to develop new GABAAR psychopharmacology by targeting these receptor-associated membrane proteins.
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