光热治疗
胶束
纳米团簇
光动力疗法
纳米技术
荧光
两亲性
聚集诱导发射
体内
增溶
荧光寿命成像显微镜
纳米医学
化学
材料科学
纳米颗粒
生物物理学
共聚物
有机化学
聚合物
水溶液
生物化学
生物
物理
生物技术
量子力学
作者
Ying Yang,Shuxin Wang,Yinlong Zhou,Xueyan Wang,Xuan Li,Anjian Xie,Manzhou Zhu
标识
DOI:10.1016/j.colsurfb.2020.111346
摘要
Theranostics including imaging and therapy has become an advanced trend for cancer treatment. It is of great significance to develop new theranostics agent for precision medicine research. In this regard, structurally precise metal nanoclusters (NCs) with ultra-small diameter and potential theranostic functions are no doubt to be a priority. In this study, we firstly investigated the photothermal and photodynamic properties of structurally precise oil-soluble bimetallic NCs (Pt1Ag28) and tactfully solubilize them into the hydrophobic inner cavity of biodegradable amphiphilic chitosan derivative (ACD) micelles via hydrophobic interaction. Positively charged Pt1Ag28@ACD with suitable particle size (∼60 nm) could not only realize effectively passive targeted delivery, but also be easily uptaken by negatively charged cancer cells for increasing targeting effect. Further, the aggregation induced emission fluorescence imaging (AIE FI)-guided enhanced photothermal/photodynamic therapy (PTT/PDT) on tumor is finally nicely achieved by the micelle solubilization of ACD micelles to Pt1Ag28 NCs, which were demonstrated by in vitro and in vivo experimental results. This theranostic platform overcomes the difficulty of lipophilic NCs entering water-phase organisms, provides enlightenment for the universal study of the interaction mechanism between organisms and oil-soluble NCs at the atomic level in future precision medicine research.
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