Advances in Research on anoikis resistance of hepatocellular carcinoma

The anoikis resistance confers the ability of cancer cells to survive and metastasize in the blood circulation without adhesion, but its effect and mechanism in intrahepatic and distant metastasis of hepatocellular carcinoma has not been fully elucidated. Recent studies have shown that certain factors or drugs may inhibit anoikis of hepatoma cells through some signaling pathways. These signaling pathways are not completely separated, they are interconnected to promote metastasis of hepatocellular carcinoma. Liver is the metabolic center of many substances, and many related factors can promote metastasis of hepatocellular carcinoma through inhibiting anoikis. In this review, we summarized the signaling pathways of anoikis resistance of hepatocellular carcinoma. Key words: Anoikis; Signal transduction; Carcinoma, hepatocellular; Neoplasm metastasis