脚手架
PLGA公司
运行x2
间充质干细胞
再生(生物学)
细胞生物学
生物医学工程
材料科学
化学
医学
成骨细胞
体外
生物
生物化学
作者
Xiaoting Zhang,Xinluan Wang,Wayne Lee,Lu Feng,Bin Wang,Qi Pan,Xiangbo Meng,Huijuan Cao,Linlong Li,Shuangfeng Wang,Shanshan Bai,Lingchi Kong,Dick Ho Kiu Chow,Ling Qin,Liao Cui,Sien Lin,Gang Li
出处
期刊:Bioengineering
[MDPI AG]
日期:2022-10-05
卷期号:9 (10): 525-525
被引量:4
标识
DOI:10.3390/bioengineering9100525
摘要
We develop a poly (lactic-co-glycolic acid)/β-calcium phosphate (PLGA/TCP)-based scaffold through a three-dimensional (3D) printing technique incorporating icaritin (ICT), a unique phytomolecule, and secretome derived from human fetal mesenchymal stem cells (HFS), to provide mechanical support and biological cues for stimulating bone defect healing. With the sustained release of ICT and HFS from the composite scaffold, the cell-free scaffold efficiently facilitates the migration of MSCs and promotes bone regeneration at the femoral defect site in the ovariectomy (OVX)-induced osteoporotic rat model. Furthermore, mechanism study results indicate that the combination of ICT and HFS additively activates the Integrin-FAK (focal adhesion kinase)-ERK1/2 (extracellular signal-regulated kinase 1/2)-Runx2 (Runt-related transcription factor 2) axis, which could be linked to the beneficial recruitment of MSCs to the implant and subsequent osteogenesis enhancement. Collectively, the PLGA/TCP/ICT/HFS (P/T/I/S) bioactive scaffold is a promising biomaterial for repairing osteoporotic bone defects, which may have immense implications for their translation to clinical practice.
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