雷公藤醇
TXNIP公司
碳水化合物反应元件结合蛋白
化学
葡萄糖稳态
转录因子
癌症研究
胰岛素抵抗
内分泌学
糖尿病
生物化学
医学
细胞凋亡
氧化应激
硫氧还蛋白
基因
作者
Duanfang Zhou,Xiaoli Li,Xiaoqiu Xiao,Gang Wang,Bo Chen,Yi Song,Xu Liu,Qichen He,Huan Zhang,Qiuya Wu,Limei Zhang,Lihong Wu,Zhengze Shen,Moustapha Hassan,Ying Zhao,Weiying Zhou
出处
期刊：Phytomedicine
[Elsevier]
日期：2022-12-27
卷期号：110: 154634-154634
被引量：21
标识
DOI：10.1016/j.phymed.2022.154634
摘要
Celastrol ameliorates T2DM through targeting ChREBP-TXNIP aix. Our study identified ChREBP as a new direct molecular target of celastrol and revealed a novel mechanism for celastrol-mediated amelioration of T2DM, which provides experimental evidence for its possible use in the treatment of T2DM and new insight into diabetes drug development for targeting TXNIP.
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