Seneca Valley Virus Induces DHX30 Cleavage to Antagonize Its Antiviral Effects

DHX30, an RNA helicase, is identified as a 3C pro -interacting protein regulating Seneca Valley virus (SVV) replication dependent on its helicase activity. DHX30 functioned as a viral-RNA binding protein that inhibited SVV replication at the early stage of virus infection.