卵巢癌
蛋白质组学
蛋白质组
疾病
卵巢癌
癌症研究
癌
病态的
生物
医学
癌症
清除单元格
肿瘤科
生物信息学
病理
内科学
基因
遗传学
作者
Jennifer X. Ji,Dawn R. Cochrane,Gian Luca Negri,Shane Colborne,Sandra E. Spencer Miko,Lynn Hoang,David Farnell,Basile Tessier‐Cloutier,Jutta Huvila,Emily F. Thompson,Samuel Leung,Derek S. Chiu,Christine Chow,Monica Ta,Martin Köbel,Lucas Feil,Michael S. Anglesio,Ellen L. Goode,Kelly L. Bolton,Gregg B. Morin,David G. Huntsman
摘要
Abstract Clear cell ovarian carcinoma (CCOC) is the second most common subtype of epithelial ovarian carcinoma. Late‐stage CCOC is not responsive to gold‐standard chemotherapy and results in suboptimal outcomes for patients. In‐depth molecular insight is urgently needed to stratify the disease and drive therapeutic development. We conducted global proteomics for 192 cases of CCOC and compared these with other epithelial ovarian carcinoma subtypes. Our results showed distinct proteomic differences in CCOC compared with other epithelial ovarian cancer subtypes including alterations in lipid and purine metabolism pathways. Furthermore, we report potential clinically significant proteomic subgroups within CCOC, suggesting the biologic plausibility of stratified treatment for this cancer. Taken together, our results provide a comprehensive understanding of the CCOC proteomic landscape to facilitate future understanding and research of this disease. © 2022 The Pathological Society of Great Britain and Ireland.
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