In newly diagnosed diabetes, hyperglycemia is associated with increased brain iron deposition, measured by MRI-based Quantitative Susceptibility Mapping (QSM)

Results suggest that increased iron deposition in the putamen, as analyzed by QSM, is worsened by hyperglycemia and insulin resistance, already when diabetes is newly diagnosed. Addressing this issue could improve on the one clinical inertia towards diabetes hand newly diagnosed, with an improvement in diabetes management strategies itself, and on the other hand, it could focus attention on increased putamen iron deposition as a predictive indicator of neurocognitive impairment in T2DM.