废止
氨基喹啉类
化学
喹啉
催化作用
组合化学
胺气处理
有机化学
作者
Nikolay Shcherbakov,Polina Kotikova,Elena I. Chikunova,Dmitry Dar’in,Vadim Yu. Kukushkin,Alexey Yu. Dubovtsev
标识
DOI:10.1002/adsc.202300484
摘要
Abstract Gold‐catalyzed interplay between ynamides and aminocarbonyls comprises a route to 2‐aminoquinolines. This modular annulation proceeds under relatively mild conditions (Ph 3 PAuCl/AgNTf 2 5 mol %, DCE, 60–80 °C), and a number of functionalities were compatible (42 examples; 25–98% yields). In contrast to a group of other gold‐catalyzed methods employing the ynamide/amine combinations for the assembly of 2‐aminoquinolines, the developed approach utilizes a diversity of aminocarbonyl substrates and, in particular, allows a variation of the substituents in the 4 th quinoline position. The synthetic potential of the obtained heterocyclic products was illustrated by post‐modifications of the quinoline backbone and the peripheral substituents.
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