神经病理性疼痛
乙醇酸
透明质酸
药理学
化学
木犀草素
生物相容性
体内
痛觉过敏
乳酸
医学
抗氧化剂
伤害
生物化学
有机化学
类黄酮
受体
生物技术
细菌
解剖
生物
遗传学
作者
So‐Yeon Park,Jee-Eun Jung,Da‐Seul Kim,Jun‐Kyu Lee,Byeong Gwan Song,Hae Eun Shin,Jae-Youn Jung,Seung‐Woon Baek,Seungkwon You,In Ho Han,Dong Keun Han
标识
DOI:10.1177/20417314231226105
摘要
Neuropathic pain (NP) is a debilitating condition stemming from damage to the somatosensory system frequently caused by nerve injuries or lesions. While existing treatments are widely employed, they often lead to side effects and lack specificity. This study aimed to alleviate NP by developing an innovative sustained-release thermosensitive hydrogel system. The system incorporates hyaluronic acid (HA)/Pluronic F127 injectable hydrogel and bupivacaine (Bup, B) in combination with poly(lactic-co-glycolic acid; PLGA)/modified magnesium hydroxide (MH)/luteolin (Lut; PML) microspheres (PML@B/Gel). The PML@B/Gel was designed for localized and prolonged co-delivery of Bup and Lut as an anesthetic and anti-inflammatory agent, respectively. Our studies demonstrated that PML@B/Gel had exceptional biocompatibility, anti-inflammatory, and antioxidant properties. In addition, it exhibited efficient pain relief in in vitro cellular assays. Moreover, this functional hydrogel showed substantial sustained drug release while diminishing microglial activation. Consequently, it effectively mitigated mechanical allodynia and thermal hyperalgesia in in vivo rat models of chronic constriction injury (CCI). Based on our research findings, PML@B/Gel emerges as a promising therapeutic approach for the protracted treatment of NP.
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