微流控
可扩展性
计算机科学
DNA
计算机数据存储
DNA测序
纳米技术
计算机硬件
材料科学
数据库
生物
遗传学
作者
Dong Dong Liu,Lih Feng Cheow
出处
期刊:Small
[Wiley]
日期:2023-12-04
标识
DOI:10.1002/smll.202309867
摘要
Due to its high information density, DNA is very attractive as a data storage system. However, a major obstacle is the high cost and long turnaround time for retrieving DNA data with next-generation sequencing. Herein, the use of a microfluidic very large-scale integration (mVLSI) platform is described to perform highly parallel and rapid readout of data stored in DNA. Additionally, it is demonstrated that multi-state data encoded in DNA can be deciphered with on-chip melt-curve analysis, thereby further increasing the data content that can be analyzed. The pairing of mVLSI network architecture with exquisitely specific DNA recognition gives rise to a scalable platform for rapid DNA data reading.
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