自愈水凝胶
细胞外基质
自愈
机械强度
材料科学
变硬
超分子化学
基质(化学分析)
纳米技术
复合材料
化学
高分子化学
分子
生物化学
医学
替代医学
有机化学
病理
作者
Xiu-Ji Du,Yongzheng Xing,Yujie Li,Muqing Cao,Fan Guo,Gui-Zhi Dong,Ziwei Shi,Xiaohui Wei,Ming Qiu,Junjie Gao,Yun‐Xiang Xu,Huaping Xu,Dongsheng Li,Yuanchen Dong
标识
DOI:10.1002/marc.202400177
摘要
Abstract The dynamic mechanical strength of the extracellular matrix (ECM) has been demonstrated to play important role in determining the cell behavior. Growing evidences suggest that the gradual stiffening process of the matrix is particularly decisive during tissue development and wound healing. Herein, we provide a novel strategy to prepare hydrogels with gradually enhanced mechanical strength. Such hydrogels could maintain the dynamic properties at their initial states, such as self‐healing and shear‐thinning properties. With subsequent slow covalent crosslinking, the stability and mechanical properties would be gradually improved. Our method is useful for sequence programmability and oxidation strategies, which has provided an alternated tool to study cell behavior during dynamic increase in mechanical strength of ECM. This article is protected by copyright. All rights reserved
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