医学
列线图
糖尿病肾病
比例危险模型
内科学
肌酐
肾脏疾病
糖尿病
病态的
肾活检
活检
肾病
生物标志物
肾
终末期肾病
胃肠病学
肿瘤科
疾病
内分泌学
生物化学
化学
作者
Jiaxin Dong,Simeng Liu,Qing Li,Lin Wu,Chengning Zhang,Suyan Duan,Bo Zhang,Yanggang Yuan,Zhimin Huang,Changying Xing,Huijuan Mao
标识
DOI:10.1016/j.diabres.2022.110142
摘要
RNA-binding protein Human antigen R (HuR) is closely related to diabetic nephropathy (DN) pathogenesis. However, the capacity of histological HuR level as a biomarker for DN progression remains unclear.A total of 147 patients with type 2 diabetes mellitus who had biopsy-proven DN were enrolled. Renal outcomes were defined by doubling serum creatinine level or progression to end-stage renal disease (ESRD). A nomogram was built to predict renal outcomes based on Cox proportional hazards regression.The median follow-up period was 31 months, during which 71 (48.30 %) patients confronted DN progression. Pearson's correlation indicated that histological HuR increased along with DN pathological class rising (r = 0.776, p < 0.001). Notably, multivariate Cox regression analysis showed that elevated HuR was associated with a greater risk of DN progression (HR 2.431, 95 %CI: 1.275-4.634, p = 0.007) beyond 6 months after renal biopsy. Patients in the higher HuR expression group had lower cumulative renal survival rates beyond the first 6 months. Simultaneously, a well-performed nomogram including HuR classification, was developed to predict the individual progression risk (C-index 0.828).Our findings demonstrated that the histologic HuR expression was an independent risk factor for kidney progression beyond 6 months after renal biopsy in DN.
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