间充质干细胞
牙周纤维
生物
牙周膜干细胞
再生(生物学)
干细胞
再生医学
细胞生物学
体内
免疫学
组织工程
医学
生物技术
牙科
生物化学
碱性磷酸酶
遗传学
酶
作者
Oriana Trubiani,Jacopo Pizzicannella,Sergio Caputi,Marco Marchisio,Emanuela Mazzon,Roberto Paganelli,Alessia Paganelli,Francesca Diomede
出处
期刊:Stem Cells and Development
[Mary Ann Liebert]
日期:2019-08-01
卷期号:28 (15): 995-1003
被引量:128
标识
DOI:10.1089/scd.2019.0025
摘要
Teeth represent a fascinating area of study in regenerative medicine, because of their unique and complex developmental origin. Several types of mesenchymal stem cells (MSCs) have been characterized in the oral cavity, and those derived from the periodontal ligament (PDL) first isolated by our group in 2005, can be expanded in a xeno-free medium preserving morphological features and markers associated with pluripotency. These postnatal MSCs can be easily recovered by noninvasive procedures and cultured. This could facilitate the use of adult stem cells in human clinical regeneration therapy. In this review we summarize the results of our studies describing morphofunctional features, surface markers, and multilineage differentiation capacity in vitro of PDL MSCs obtained in our laboratories. In vivo characterization of PDL stem cell (PDLSC) location and heterogeneity are still lacking. However, we describe studies exploring the potential use of PDLSC to treat both periodontal diseases and regeneration of other tissues. These MSCs may have an advantage in possessing also angiogenetic, immunoregulatory, and anti-inflammatory properties. The secretome of such cells contains several interesting molecules mimicking the effects of the producer cells. We describe some recent studies from our group on the use of conditioned medium from PDL MSCs, and purified extracellular vesicles therein contained, in animal models of experimental autoimmune encephalomyelitis and their potential application to human disease.
科研通智能强力驱动
Strongly Powered by AbleSci AI