神经发生
海马结构
神经科学
海马体
齿状回
心理学
生物
神经干细胞
双皮质醇
作者
Desiree R Seib,Delane F Espinueva,Oren Princz-Lebel,Erin Chahley,Stan B. Floresco,Jason S. Snyder
出处
期刊:bioRxiv
日期:2018-08-23
卷期号:: 399261-
被引量:1
摘要
Adult hippocampal neurogenesis is implicated in a number of disorders where reward processes are disrupted but whether new neurons regulate specific reward behaviors remains unknown. We find that blocking neurogenesis in rats reduces activation of the ventral dentate gyrus and causes a profound aversion for delayed rewards. Delay-based decision-making restructured dendrites and spines in adult- born neurons, consistent with activity-dependent neuronal recruitment. These findings identify a novel role for neurogenesis in decisions about future rewards, which is compromised in disorders where short-sighted gains are preferred at the expense of long-term health.
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