米安色林
耐受性
抗胆碱能
医学
安慰剂
止痛药
焦虑
腹痛
慢性疼痛
抗抑郁药
麻醉
内科学
精神科
不利影响
替代医学
病理
标识
DOI:10.3109/08039489309104100
摘要
Mianserin is a tetracyclic antidepressant that has gained popularity in Europe owing to lack of anticholinergic side effects and good tolerability. Being a histamine-1 and -2 receptor antagonist and an alpha-2 receptor blocker suggests that it should be of particular value in somatoform gastrointestinal disorders. In an open trial mianserin was given for 6 weeks to 24 patients with chronic idiopathic abdominal pain of more than 2 years' duration. Patients with a diagnosis of depressive or anxiety disorders were excluded. Daily dosage varied from 90 to 120 mg. Other psychopharmacologic or analgesic medication was not allowed during the trial. Pain response was measured by means of the Clinical Global Improvement Scale and daily self-reporting. Five patients dropped out. Of 19 completers, 15 reported significantly reduced pain. Placebo-controlled studies are needed to validate these encouraging results.
科研通智能强力驱动
Strongly Powered by AbleSci AI