小胶质细胞
促炎细胞因子
趋化因子
免疫学
细胞因子
炎症
中枢神经系统
白细胞介素
神经炎症
肿瘤坏死因子α
医学
生物
内分泌学
作者
Laura Ehrlich,Shuxian Hu,Wen S. Sheng,Richard L. Sutton,Gaylan L. Rockswold,Phillip K. Peterson,Chun C. Chao
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:1998-02-15
卷期号:160 (4): 1944-1948
被引量:189
标识
DOI:10.4049/jimmunol.160.4.1944
摘要
Abstract IL-8 involvement in neutrophil activation and chemotaxis may be important in inflammatory responses within the central nervous system, secondary to meningitis, encephalitis, and traumatic injury. The source of IL-8 within the brain during these inflammatory processes, however, is unknown. To explore the role of microglia in the production of IL-8, human fetal microglia, which are the resident macrophages of the brain, were treated with LPS and pro- and anti-inflammatory cytokines to determine their effects on IL-8 production. We found that IL-8 protein levels increased in response to LPS or IL-1β, or to TNF-α, which also corresponded to elevated IL-8 mRNA levels by RT-PCR. Pretreatment with IL-4, IL-10, or TGF-β1 potently inhibited the stimulatory effects of these proinflammatory agents. These findings indicate that human microglia synthesize IL-8 in response to proinflammatory stimuli, and that anti-inflammatory cytokines down-regulate the production of this chemokine. These results may have important therapeutic implications for certain central nervous system insults involving inflammation.
科研通智能强力驱动
Strongly Powered by AbleSci AI