表观基因组
重编程
表观遗传学
生物
表观遗传学
组蛋白
甲基转移酶
组蛋白甲基转移酶
计算生物学
遗传学
DNA甲基化
细胞生物学
甲基化
基因
基因表达
作者
Lindsey S. Treviño,Quan Wang,Cheryl L. Walker
标识
DOI:10.1016/j.pbiomolbio.2015.02.013
摘要
Epigenetic reprogramming that occurs during critical periods of development can increase the susceptibility to many diseases in adulthood. Programming of the epigenome during development occurs via the activity of a variety of epigenetic modifiers, including “readers, writers and erasers” of histone methyl marks. Posttranslational modification of these programmers can alter their activity, resulting in global or gene-specific changes in histone methylation and gene transcription. This review summarizes what is currently known about phosphorylation of histone methyltransferases (“writers”), demethylases (“erasers”) and effector proteins (“readers) that program the epigenome, and the impact of this posttranslational modification on their activity. Understanding how the activity of these epigenetic programmers is perturbed by environmental exposures via changes in phosphorylation is key to understanding mechanisms of developmental reprogramming and the epigenetic basis of health and disease.
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