普伐他汀
医学
心肌梗塞
内科学
心脏病学
安慰剂
他汀类
冲程(发动机)
人口
临床试验
胆固醇
病理
机械工程
环境卫生
工程类
替代医学
作者
Robert P. Byington,J. Wouter Jukema,J. T. Salonen,Bertram Pitt,A. V. G. Bruschke,Helena Hoen,Curt D. Furberg,G.B. John Mancini
出处
期刊:Circulation
[Ovid Technologies (Wolters Kluwer)]
日期:1995-11-01
卷期号:92 (9): 2419-2425
被引量:258
标识
DOI:10.1161/01.cir.92.9.2419
摘要
Background It has been documented that the HMG coenzyme A reductase inhibitors, or statins, can decrease cardiovascular events and mortality in patients with clinical coronary disease and moderately to severely elevated lipid levels. Additional data are required to demonstrate a reduction of vascular events in coronary patients with less than severely elevated lipid levels and in subgroups of this population. Methods and Results Clinical data from four atherosclerosis regression trials that evaluated pravastatin were pooled for a predetermined analysis of the effect of that agent on the risk of coronary events. All trials were double-masked, placebo-controlled designs that used pravastatin as monotherapy for 2 to 3 years. The 1891 participants in the trials had evidence of atherosclerosis and mildly to moderately elevated lipid levels. For fatal or nonfatal myocardial infarction, there was a 62% reduction in events attributable to pravastatin ( P =.001). This effect was evident in younger and older patients, men and women, and patients with and without histories of hypertension and prior infarction. There was a 46% reduction in all-cause mortality ( P =.17), which, although not statistically significant, is consistent with the results of other statin trials. There also was a 62% reduction in the risk of fatal or nonfatal stroke ( P =.054). Conclusions These pooled results provide strong evidence that pravastatin reduces the risk of cardiovascular events in patients with atherosclerotic disease and mildly to moderately elevated lipid levels. The benefit for reducing myocardial infarction is evident in older and younger patients, men and women, and patients with and without histories of hypertension and prior infarction.
科研通智能强力驱动
Strongly Powered by AbleSci AI