限制
免疫系统
癌症
脂质运载蛋白
癌症研究
蛛网膜下腔
癌细胞
中枢神经系统
转移
医学
脑脊液
生物
病理
神经科学
免疫学
内科学
工程类
机械工程
作者
Yudan Chi,Ján Remšík,Vaidotas Kiseliovas,Camille Derderian,Uğur Şener,Majdi Alghader,Fadi Saadeh,Katie Nikishina,Tejus A. Bale,Christine A. Iacobuzio-Donahue,Tiffany Thomas,Dana Pe’er,Linas Mažutis,Adrienne Boire
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2020-07-17
卷期号:369 (6501): 276-282
被引量:139
标识
DOI:10.1126/science.aaz2193
摘要
Ironing out a survival strategy Metastatic cells display a notable ability to adapt to—and even thrive in—harsh microenvironments. One extreme example is leptomeningeal metastases (LM), cancer cells that enter a region of the central nervous system called the subarachnoid space, which is filled with cerebral spinal fluid (CSF). This anatomic site has a limited supply of micronutrients such as iron, and it harbors immune cells. Chi et al. used single-cell RNA sequencing to study CSF samples from cancer patients with LM (see the Perspective by Garzia and Taylor). They found that LM cells express and use components of a high-affinity iron-capturing system. Through this mechanism, the LM cells avoid the adverse effects of iron deprivation and potentially escape immune attack by limiting the supply of iron to macrophages. Science this issue p. 276 ; see also p. 250
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