化学
光化学
电化学
化学计量学
亲核细胞
催化作用
组合化学
氯
烷基化
有机化学
物理化学
电极
作者
Hai‐Chao Xu,Pengyu Chen
标识
DOI:10.1002/anie.202005724
摘要
Abstract Heteroarenes are structural motifs found in many bioactive compounds and functional materials. Dehydrogenative cross‐coupling of heteroarenes with aliphatic C−H bonds provides straightforward access to functionalized heteroarenes from readily available materials. Established methods employ stoichiometric chemical oxidants under conditions of heating or light irradiation. By merging electrochemistry and photochemistry, we have achieved efficient photoelectrochemical dehydrogenative cross‐coupling of heteroarenes and C(sp 3 )−H donors through H 2 evolution, without the addition of metal catalysts or chemical oxidants. Mechanistically, the C(sp 3 )−H donor is converted to a nucleophilic carbon radical through H‐atom transfer with chlorine atom, which is produced by light irradiation of anodically generated Cl 2 from Cl − . The carbon radical then undergoes radical substitution to the heteroarene to afford alkylated heteroarene products.
科研通智能强力驱动
Strongly Powered by AbleSci AI