实验性自身免疫性脑脊髓炎
免疫系统
葡聚糖
多糖
效应器
细胞生物学
T细胞
生物化学
酵母
甘露聚糖
生物
化学
微生物学
免疫学
作者
Changhon Lee,Ravi Verma,Seohyun Byun,Eun-Ji Jeun,Gi-Cheon Kim,Suyong Lee,Hye-Ji Kang,Chan Johng Kim,Garima Sharma,Abhishake Lahiri,Sandip Paul,Kwang Soon Kim,Dong Soo Hwang,Yoichiro Iwakura,Immacolata Speciale,Antonio Molinaro,Cristina De Castro,Dipayan Rudra,Sungbin Im
标识
DOI:10.1038/s41467-021-23929-9
摘要
Yeast is an integral part of mammalian microbiome, and like commensal bacteria, has the potential of being harnessed to influence immunity in clinical settings. However, functional specificities of yeast-derived immunoregulatory molecules remain elusive. Here we find that while under steady state, β-1,3-glucan-containing polysaccharides potentiate pro-inflammatory properties, a relatively less abundant class of cell surface polysaccharides, dubbed mannan/β-1,6-glucan-containing polysaccharides (MGCP), is capable of exerting potent anti-inflammatory effects to the immune system. MGCP, in contrast to previously identified microbial cell surface polysaccharides, through a Dectin1-Cox2 signaling axis in dendritic cells, facilitates regulatory T (Treg) cell induction from naïve T cells. Furthermore, through a TLR2-dependent mechanism, it restrains Th1 differentiation of effector T cells by suppressing IFN-γ expression. As a result, administration of MGCP display robust suppressive capacity towards experimental inflammatory disease models of colitis and experimental autoimmune encephalomyelitis (EAE) in mice, thereby highlighting its potential therapeutic utility against clinically relevant autoimmune diseases.
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