树枝状大分子
纳米载体
纳米医学
生物相容性
纳米技术
药物输送
药品
化学
癌症治疗
共轭体系
癌症治疗
内吞作用
毒品携带者
癌症
药理学
组合化学
材料科学
医学
纳米颗粒
聚合物
有机化学
生物化学
内科学
细胞
作者
Serge Mignani,Joáo Rodrigues,Helena Tomás,Maria Zabłocka,Xiangyang Shi,Anne‐Marie Caminade,Jean Pierre Majoral
摘要
For the first time, an overview of dendrimers in combination with natural products and analogues as anti-cancer agents is presented. This reflects the development of drug delivery systems, such as dendrimers, to tackle cancers. The most significant advantages of using dendrimers in nanomedicine are their high biocompatibility, good water solubility, and their entry - with or without encapsulated, complexed or conjugated drugs - through an endocytosis process. This strategy has accelerated over the years in order to develop nanosystems as nanocarriers, to decrease the intrinsic toxicity of anti-cancer agents, to decrease the drug side effects, to increase the efficacy of the treatment, and consequently to improve patient compliance.
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