高同型半胱氨酸血症
蛋氨酸
内科学
同型半胱氨酸
内分泌学
心功能曲线
维生素
B族维生素
医学
生物
心力衰竭
氨基酸
生物化学
作者
Jovana Jeremic,Tamara Nikolic Turnic,Vladimir Zivkovic,Nevena Jeremic,Isidora Milosavljevic,Ivan Srejovic,Radmila Obrenovic,Snezana Jancic,Milena Rakocevic,Stevan Matic,Dragan Djuric,Vladimir Jakovljevic
标识
DOI:10.1111/1440-1681.12930
摘要
This research is designed to test the hypothesis that elevated homocysteine (Hcy) levels in vivo, caused by a deficit in vitamin B complex, promote changes in cardiac function and redox status that lead to heart failure. In order to conduct the study, we used adult male Wistar albino rats (n = 30; 4 weeks old; 100 ± 15 g body weight). Hyperhomocysteinaemia (HHcy) in these animals was achieved by dietary manipulation. For 4 weeks, the animals were fed with a standard rodent chow (control, CF), a diet enriched in methionine with no deficiency in B vitamins (i.e., folic acid, B6 and B12) (HMNV) or a diet enriched in methionine and deficient in B vitamins (HMLV). After 28 days of dietary manipulation, all animals were killed. The rat hearts were isolated and retrogradely perfused according to the Langendorff technique at a gradually increasing perfusion pressure. We found a negative correlation between elevated serum Hcy and total body and heart weight. The maximum rate of left ventricular pressure development was significantly increased in the HMNV group compared with in the other groups. Systolic left ventricular pressure was significantly changed in all groups. HHcy induces remodelling of the cardiac tissues, as moderate HHcy is associated with more prominent interstitial and perivascular fibrosis. Our results suggest that a high methionine diet without vitamin B complex causes profound negative effects associated with HHcy.
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