[Proteomic-driven precision medicine research in hepatocellular carcinoma].

Proteomics is the study of proteins-the direct executor of life activities. Protein plays a vital role in the development and growth of human body and the genesis and development of diseases. It is the most widely used clinical marker type and the direct drug target. In recent years, the advance of proteomic core technology with chromatography and mass spectrometry has promoted the rapid development in the depth and breadth of proteomic research, and its application in the large cohort of hepatocellular carcinoma opens a new era of proteomics-driven precision medicine (PDPM). This review highlights the proteomic research in new techniques, directions and discoveries of hepatocellular carcinoma research in recent years, providing new ideas and references for clinicians to understand proteomics, and to use proteomics to assist in the diagnosis of diseases and the development of personalized therapies.蛋白质组学研究的对象是生命活动的直接执行者——蛋白质，蛋白质在人体的发育生长和疾病发生发展过程中起着至关重要的作用，是目前临床应用最广泛的标志物类型，也是最直接的药物作用靶标。近年来，以色谱和质谱技术为核心的蛋白组学技术的进步，推动了蛋白质组学研究在深度和广度上的快速发展，其在肝细胞癌临床队列样本研究中的应用，开启了“蛋白质组学驱动的精准医学”新时代。现对近年来蛋白质组学研究凸现的新技术、新方向和在肝癌研究中的新发现做一综述，为临床医生了解蛋白质组学，并利用蛋白质组学助力疾病的诊断和个性化治疗药物研发提供新的思路和参考。.