体内
纳米颗粒
牛血清白蛋白
松弛法
磁共振造影剂
化学
体外
MTT法
材料科学
核化学
纳米技术
生物物理学
核磁共振
磁共振成像
色谱法
生物化学
医学
放射科
自旋回波
物理
生物技术
生物
作者
Khadijeh Alipanah-poor,Roghayeh Sheervalilou,Rasoul Irajirad,Abolfazl Sarikhani,Zahed Tavangari,Zahra Alamzadeh,Habib Ghaznavi,Samideh Khoei
标识
DOI:10.1016/j.mri.2023.06.013
摘要
In recent years, the use of nanoparticles has been developed to improve MRI contrast. To improve the contrast agents in image-guided therapy by Multifunctional nanoparticles, in this study, we synthesized a theranostic magneto-plasmonic nanocomplex based on magnetic iron oxide nanoparticles and bovine serum albumin-modified gold nanorod (Au@BSA-Fe3O4@CMD). The purpose of synthesizing these nanoparticles was to use them as MRI contrast agent and photothermal agents in in vitro and in vivo experiments. Initially, the properties of the synthesized nanoparticles were investigated by methods such as DLS, TEM, FTIR. MTT assay was used to evaluate the toxicity of nanoparticles. Finally, to evaluate the contrast ability of nanoparticles, MRI images were taken in in vitro and in vivo conditions and then the images were analyzed. MTT test results on CT26 cell line showed no significant cytotoxicity for Au@BSA-Fe3O4@CMD nanoparticles at concentrations up to 20 ppm. The in vitro results demonstrated that the Au@BSA-Fe3O4@CMD nanocomplex has high T2 relaxation rate and great relaxivities (r2 = 140.14 mM−1 s−1, r1 = 2.066 mM−1 s−1, r2/r1 = 67.83). For in vivo conditions, a decrease in T2 signal of 9.64 and 11.01, respectively, was observed for intratumoral and intraperitoneal injection of nanoparticles. These in vitro and in vivo studies show that Au @ BSA-Fe3O4@CMD nanoparticles can significantly reduce the signal intensity of T2-weight MRI images, and therefore can offer significant potential as a theranostic platform for effective tumor MR imaging.
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