羟醛反应
化学
磺胺
苏氨酸
加合物
有机催化
立体选择性
有机化学
催化作用
对映选择合成
氨基酸
产量(工程)
生物化学
丝氨酸
酶
材料科学
冶金
作者
Ryoga Hikawa,Mio Shimogaki,Taichi Kano
标识
DOI:10.1002/ajoc.202300113
摘要
Abstract Novel threonine‐derived amino sulfonamide organocatalysts were developed and applied to the asymmetric aldol reactions. The reactions of cyclohexanones with aromatic aldehydes catalyzed by the threonine‐derived tosylamide provided anti ‐aldol adducts in good yield with high diastereo‐ and enantioselectivity. On the other hand, syn ‐aldol adducts were obtained in the reactions between α‐siloxyacetone and aromatic aldehydes using threonine‐derived triflamide catalyst. In both cases, a significant improvement in diastereoselectivity was observed compared to threonine‐derived carboxylic acid catalyst.
科研通智能强力驱动
Strongly Powered by AbleSci AI