化学
膜
基质(化学分析)
金属
伤口愈合
生物化学
有机化学
免疫学
色谱法
生物
作者
Han-Xiao Feng,Xiaodong Su,Dahai Hu,Yi-Fei Hui,Hongxin Su,Jilin Jiang,Ruyi Ji,Shulin Li,Zu‐Jin Lin,Faqiang Tang
出处
期刊:Inorganic Chemistry
[American Chemical Society]
日期:2025-06-24
卷期号:64 (26): 13557-13568
被引量:8
标识
DOI:10.1021/acs.inorgchem.5c02508
摘要
Bacterial infections pose an increasing threat to human health. Chemodynamic therapy (CDT), which utilizes nanozymes to catalyze H2O2 into highly toxic hydroxyl radicals (·OH), offers a promising disinfection strategy because of its high efficacy, broad-spectrum antibacterial activity, and low risk of inducing drug resistance. Herein, we developed a self-powered CDT nanocomposite, CaO2@PCN-222(Fe), via a facile one-pot synthesis for wound disinfection. In infected wounds, the CaO2 component of the composite gradually hydrolyzes to H2O2, while the PCN-222(Fe) component acts as peroxidase mimics to efficiently catalyze the generated H2O2 into ·OH, thus achieving self-powered CDT. In vitro assays confirmed that the minimum bactericidal concentration of the composite against Staphylococcus aureus is as low as 31.25 μg mL–1. Furthermore, in vivo assays demonstrated that the composite could effectively accelerate infected wound healing. To broaden application scenarios, the composite was further integrated into poly(vinylidene fluoride) (PVDF) to form CaO2@PCN-222(Fe)@PVDF mixed matrix membranes (MMMs), which inherit the self-powered CDT capability, exhibiting high antimicrobial activity and promoting infected wound healing. Notably, no significant toxicity was observed for CaO2@PCN-222(Fe) and its MMMs. This work presents an efficient self-powered CDT modality, combining the advantages of CaO2 and peroxidase mimics for treating bacterial infections and promoting infected wound healing.
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