医学
脂肪肝
危险系数
疾病
荟萃分析
内科学
非酒精性脂肪肝
肾脏疾病
置信区间
作者
Jingxuan Quek,Cheng Han Ng,Ansel Shao Pin Tang,Nicholas Chew,Mark Y Chan,Chin Meng Khoo,Chen Poh Wei,Yip Han Chin,Phoebe Wen Lin Tay,Gina Lim,Darren Jun Hao Tan,Wen Hui Lim,Kai En Chan,Margaret Teng,Ee Hong Tan,Nobuharu Tamaki,Daniel Q. Huang,Mohammad Shadab Siddiqui,Dan Yock Young,Mazen Noureddin,Mark Muthiah
标识
DOI:10.1016/j.eprac.2022.03.016
摘要
The recent introduction of the term metabolic associated fatty liver disease (MAFLD) sought to reclassify nonalcoholic fatty liver disease (NAFLD). MAFLD is thought to improve the encapsulation of metabolic dysregulation. However, recent evidence has found significant differences between MAFLD and NAFLD, and prevailing knowledge has largely arisen from studies on NAFLD. Hence, we conducted a meta-analysis and systematic review of the outcomes associated with MAFLD.MEDLINE and Embase databases were searched for articles relating to outcomes in MAFLD. Analysis was conducted in random effects with hazard ratios (HRs) to account for longitudinal risk assessment of mortality and systemic complications.A total of 554 articles were identified, of which 17 articles were included. MAFLD resulted in an increase in the overall mortality (HR, 1.24; confidence interval [CI], 1.13-1.34), cancer-related mortality (HR, 1.27; CI, 1.01-1.54), and cardiovascular disease mortality (HR, 1.28, 1.03-1.53; P = .04) compared with non-MAFLD. MAFLD also increases the risk of cardiovascular events (HR, 1.49; CI, 1.34-1.64; P < .01), stroke (HR, 1.55; CI, 1.37-1.73; P < .01), and chronic kidney disease (HR, 1.53; CI, 1.38-1.68). The presence of MAFLD was also associated with an increased risk of heart failure, obstructive sleep apnea, and malignancy.MAFLD can significantly elevate the risk of systemic diseases and mortality. The care of MAFLD thus requires interdisciplinary collaboration, and future clinical trials conducted on MAFLD should aim to reduce the incidence of end-organ damage aside from improving liver histology.