小胶质细胞
神经炎症
认知功能衰退
肠道菌群
生物
认知
疾病
神经科学
肠-脑轴
串扰
痴呆
衰老的大脑
免疫学
炎症
医学
病理
物理
光学
作者
Rui Zhou,Shufang Qian,William C. Cho,Jinyun Zhou,Chentao Jin,Zhiying Yan,Jing Wang,Xiaohui Zhang,Zhoujiao Xu,Mei Tian,Lawrence Chan,Hong Zhang
出处
期刊:Aging Cell
[Wiley]
日期:2022-03-29
卷期号:21 (5)
被引量:24
摘要
Aging is an inevitable process that all individuals experience, of which the extent differs among individuals. It has been recognized as the risk factor of neurodegenerative diseases by affecting gut microbiota compositions, microglia, and cognition abilities. Aging-induced changes in gut microbiota compositions have a critical role in orchestrating the morphology and functions of microglia through the gut-brain axis. Gut microbiota communicates with microglia by its secreted metabolites and neurotransmitters. This is highly associated with age-related cognitive declines. Here, we review the main composition of microbiota in the aged individuals, outline the changes of the brain in age-related cognitive decline from a neuroinflammation perspective, especially the changes of morphology and functions of microglia, discuss the crosstalk between microbiota and microglia in the aged brain and further highlight the role of microbiota-microglia connections in neurodegenerative diseases (Alzheimer's disease and Parkinson's disease).
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