生物
先天免疫系统
细胞生物学
再生(生物学)
肌发生
祖细胞
脂肪生成
骨骼肌
干细胞
免疫学
心肌细胞
间充质干细胞
解剖
免疫系统
作者
Jose Heredia,Lata Mukundan,Francis M. Chen,Alisa A. Mueller,Rahul C. Deo,Richard M. Locksley,Thomas A. Rando,Ajay Chawla
出处
期刊:Cell
[Elsevier]
日期:2013-04-01
卷期号:153 (2): 376-388
被引量:638
标识
DOI:10.1016/j.cell.2013.02.053
摘要
In vertebrates, activation of innate immunity is an early response to injury, implicating it in the regenerative process. However, the mechanisms by which innate signals might regulate stem cell functionality are unknown. Here, we demonstrate that type 2 innate immunity is required for regeneration of skeletal muscle after injury. Muscle damage results in rapid recruitment of eosinophils, which secrete IL-4 to activate the regenerative actions of muscle resident fibro/adipocyte progenitors (FAPs). In FAPs, IL-4/IL-13 signaling serves as a key switch to control their fate and functions. Activation of IL-4/IL-13 signaling promotes proliferation of FAPs to support myogenesis while inhibiting their differentiation into adipocytes. Surprisingly, type 2 cytokine signaling is also required in FAPs, but not in myeloid cells, for rapid clearance of necrotic debris, a process that is necessary for timely and complete regeneration of tissues.
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