纳米颗粒
材料科学
体内
膜
癌细胞
纳米技术
蛋白质吸附
生物物理学
癌症
化学
生物化学
聚合物
生物
遗传学
生物技术
复合材料
作者
Lang Rao,Qian‐Fang Meng,Lin‐Lin Bu,Bo Cai,Qin Huang,Zhi‐Jun Sun,Wenfeng Zhang,Andrew Li,Shishang Guo,Wei Liu,Tza‐Huei Wang,Xingzhong Zhao
标识
DOI:10.1021/acsami.6b14450
摘要
Upconversion nanoparticles (UCNPs) with superior optical and chemical features have been broadly employed for in vivo cancer imaging. Generally, UCNPs are surface modified with ligands for cancer active targeting. However, nanoparticles in biological fluids are known to form a long-lived “protein corona”, which covers the targeting ligands on nanoparticle surface and dramatically reduces the nanoparticle targeting capabilities. Here, for the first time, we demonstrated that by coating UCNPs with red blood cell (RBC) membranes, the resulting cell membrane-capped nanoparticles (RBC-UCNPs) adsorbed virtually no proteins when exposed to human plasma. We further observed in various scenarios that the cancer targeting ability of folic acid (FA)-functionalized nanoparticles (FA-RBC-UCNPs) was rescued by the cell membrane coating. Next, the FA-RBC-UCNPs were successfully utilized for enhanced in vivo tumor imaging. Finally, blood parameters and histology analysis suggested that no significant systematic toxicity was induced by the injection of biomimetic nanoparticles. Our method provides a new angle on the design of targeted nanoparticles for biomedical applications.
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