抗菌剂
细菌
致病菌
抗生素
药品
香烟烟雾
化学
微生物学
烟雾
体内
毒理
生物
药理学
生物技术
有机化学
遗传学
作者
Yuxiang Song,Fang Lü,Li Hao,Huibo Wang,Mengling Zhang,Yang Liu,Zhenhui Kang
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2018-11-29
卷期号:1 (6): 1871-1879
被引量:52
标识
DOI:10.1021/acsabm.8b00421
摘要
Infection of pathogenic bacteria and the abuse of antibiotics are the main factors in worldwide health issues. A number of nanomaterials have been fabricated to directly battle drug-resistant bacteria. However, few studies have referred to the relation between common daily carbon nanoparticles (e.g., automobile exhaust and cigarette smoke) and antimicrobial activities. Herein, carbon dots (CDs) extracted from cigarette smoke are introduced, showing low in vivo and in vitro toxicity. These CDs show broad-spectrum antimicrobial activities that originate from the destruction of the double helix structure of DNA. CDs can degrade to smaller particles and organic fragments with the existence of horseradish peroxidase (HRP) and H2O2 in 7 days, during which CDs can function as an effective antibiotic within the early days and then gradually degrade and lose the antimicrobial effects until finally being eliminated through metabolism. Our findings relate common daily carbon nanoparticles from cigarette smoke with antimicrobial activities, suggesting that the CDs can function as an effective broad-spectrum antibiotic, even against drug-resistant bacteria.
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